The Philadelphia chromosome results from which translocation?

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Study for the WGU NURS6800 D116 Advanced Pharmacology Exam. Use flashcards and multiple-choice questions with hints and explanations. Prepare thoroughly for your exam!

Multiple Choice

The Philadelphia chromosome results from which translocation?

Explanation:
This translocation creates the Philadelphia chromosome by fusing the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9, resulting in the BCR-ABL fusion. That fusion produces a constitutively active tyrosine kinase that drives uncontrolled cell growth, a hallmark of chronic myeloid leukemia and a key target for tyrosine kinase inhibitors like imatinib. The other translocations involve different genes and drive other cancers (for example, 8;14 with c-MYC in Burkitt lymphoma, 11;14 with cyclin D1 in mantle cell lymphoma, and 15;17 with PML-RARA in acute promyelocytic leukemia).

This translocation creates the Philadelphia chromosome by fusing the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9, resulting in the BCR-ABL fusion. That fusion produces a constitutively active tyrosine kinase that drives uncontrolled cell growth, a hallmark of chronic myeloid leukemia and a key target for tyrosine kinase inhibitors like imatinib. The other translocations involve different genes and drive other cancers (for example, 8;14 with c-MYC in Burkitt lymphoma, 11;14 with cyclin D1 in mantle cell lymphoma, and 15;17 with PML-RARA in acute promyelocytic leukemia).

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