In the context of GLP-1 receptor agonists, which symptom is most commonly associated with their initial use?

• A. Nausea.
• B. Hyperkalemia.
• C. Weight gain.
• D. Insomnia.

Answer: (A)

GLP-1 receptor agonists commonly cause GI side effects early in therapy because they slow gastric emptying and alter central appetite signaling. This slowing of gastric transit can produce nausea as the stomach adapts to the new rate of emptying, especially when therapy is started or dose is increased. The nausea is typically most noticeable during the initial weeks and often diminishes as the patient titrates to a maintenance dose and the body adjusts.

Understand that this class also tends to promote weight loss rather than gain, and hyperkalemia is not a typical concern with these agents. Insomnia isn’t a hallmark reaction either. Some patients may experience mild vomiting or abdominal discomfort, but nausea remains the most common initial symptom.